April 15, 2023, by Jeffrey Morrison Sanderson, J. T., Slobbe, L., Lansbergen, G. W., Safe, S., and van den Berg, M. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells. Chem.Res.Toxicol. Check the article to learn more about the mast cell. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. View abstract. View abstract. You may have shorter menstrual cycles, lengthier periods, or two monthly periods. View abstract. 120 Count (Pack of 1) No reviews. The recipe of Sauted Zucchini is not only detox friendly, but also easy to make. View abstract. Thats because the underlying cause of the symptoms is radical hormone fluctuations. View abstract. 2005 - 2023 WebMD LLC, an Internet Brands company. View abstract. DIM is often used in combination with progesterone replacement therapy and other BHRT therapies for best results. What Is Diindolylmethane (DIM): Benefits, Uses, Side Effects - Swolverine Diindolylmethane (DIM) has been the topic ofrecent discussions surroundinghormonal health. Less common side effects included nausea, diarrhea, vomiting and a skin rash. Natl Inst Health, Natl Inst Environmental Health Sci. In particular, people of northern European ancestry may have genetic factors that can increase this half-life to around 30 hours, so in these individuals, the withdrawal timeline will be significantly longer, although this also means that the symptoms of dextromethorphan withdrawal will be less intense. Nearly 13 percent of the women reported changes in their menstrual cycle when they took DIM(R). Thyroid. Why DIM Alone Isn't Enough For Estrogen Dominance Also, if using topically, be sure to check if youre allergic by placing a test patch of oil on your skin and seeing if you have a reaction. View abstract. There was some speculation about the efficacy of DIM as an estrogen blocker so I'm a little worried about taking more.. 1. 127,8 (2010): 1748-57. If you have headaches or other symptoms that cause concern once youve started the detox, check in with your doctor to make sure that its in your best interest to continue. Diindolylmethane might act like estrogen in the body, but might also block estrogen effects. Increased male hormones can cause an increase in facial hair growth, acne, and hair loss. View abstract. The estrogen metabolites produced by DIM bind to specific proteins that can help improve hormonal imbalances. Yang G, Wang Y, Tian J, Liu JP. RELATED ARTICLE How To Effectively Reduce Your Stress. Sasieni, P. Chemoprevention of cervical cancer. Female sex hormones help conduct our sleep cycle and overall mood; How Baseline+ May Help, Why you should consider switching your energy supplements. Learn how to log information about your pain levels, potential triggers. The Side Effects of Diindolylmethane Supplement | livestrong Headache diaries keep track of the number and types of headaches you have. Phillippe Greenough. 2011 Mar;21(3):299-304. Four . Other signs that your immune system is fighting for you Just like lymph nodes, allergy symptoms can arise when the immune system is fighting to eliminate toxins. View abstract. When 353 women at risk for developing cervical cancer took DIM supplements, nearly 70 percent experienced some type of nonserious side effect, according to a study published in the "British Journal of Cancer" in November 2011. Calls to any sponsored hotline (non-facility) will be answered by: If you wish to contact a specific medical detox center then find a specific detox center using our detox locator tool. These symptoms can include, headaches, irritability, body aches, flulike symptoms, changes in bowel movements (most commonly diarrhea), fatigue and insomnia. So its not uncommon for us to field questions about treatments or supplements that are not vein related. 2010;116(3):464-467. Castaon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. . This may result in: Along with headaches, other symptoms during a detox diet may include: When reading about these detoxes, the symptoms may be called various names including healing reactions, cleansing reactions, detox symptoms, and healing crises. BioResponse DIMprovides 25 mg per serving of a highly absorbable form of DIM, an important metabolite of indole-3-carbinol. 1999;19(4B):3199-3203. Denver, CO 80222. 2001;61(1):40-48. The next, they may be close to zero. The Benefits of Calcium D-Glucarate - Dr. Jolene Brighten Zucchini, also known as courgette, is a nutrient-dense vegetable that is low in calories but high in several important vitamins and minerals. Dim will kick in detox symptoms for about 2 or 3 weeks while it gets rid of your bad estrogens and xenoestrogens from the enviourment. The effects of dextromethorphan are also dose-dependent, with small amounts producing depressive effects and large amounts producing dissociative and hallucinogenic effects. How to Use DIM for Insomnia (estrogen detox) - Eat Beautiful Balk JL. 2009;15(8):1164-1173. The protea flower symbolizes growth and transformation. Biochem.Pharmacol. In vitro and in animal studies suggest DIM has anti-inflammatory , antiproliferative . Find out about home remedies to ease. Most people find that their urine is noticeably darker (usually some variation of burnt orange). While DIM can be obtained naturally by eating tons cruciferous veggies its not realistic to achieve the benefits of these foodswithoutsupplementation. The exact way this works is unclear, although it most likely has to do with the combination of NMDA antagonism, -1 receptor stimulation, and serotonin reuptake inhibition, somewhat similar to more classic hallucinogens. 2006;20(2):295-305. J.Nutr.Biochem. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Ishikawa T, Glidewell-kenney C, Jameson JL. If you want to learn more about what DIM is and how it works, do check out one of our previous posts on DIM. Taking a probiotic and consuming gut friendly foods such as kefir, yogurt, kimchi, and sauerkraut supports the gut and ensures and efficient detox pathway. DIM also increases the uptake of naturally occurring testosterone in your body therefore stimulating muscle growth and optimizing fat loss. Allergies arent the only problem caused by overactive mast cells. View abstract. For example, DIM works on phase I liver detoxification, while calcium D-glucarate works on phase II and elimination through the bowels (what some call phase 3). Although DIM supplement is available over the counter, working with a physician who understands how DIM works and its many benefits is crucial if you want the best results. View abstract. But in some cases, diindolylmethane might oppose the effects of estrogen. The symptoms of dextromethorphan withdrawal can sometimes be quite intense and may be dangerous in some circumstances, although this is very rare. 2008;138(1):17-23. Diindolylmethane might change how quickly the liver breaks down these medications. I experienced terrible headaches, indigestion, nausea, vomiting. 1-15-2010;70(2):646-654. To get enough DIM through food, one would have to eat at least 2 lbs. View abstract. View abstract. 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Since DIM affects how a womans body produces estrogen metabolites, it can be an effective addition to a hormone replacement treatment plan. 6 (Nov., 2000), pp. As you'll remember from above, progesterone converts to a sedating neurosteroid which soothes GABA receptors in the brain. DIM converts estrogen and reduces its effect. Please consult a physician or other health care professional for your specific health care and/or medical needs or concerns. J Steroid Biochem Mol Biol. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot studyThyroid : official journal of the American Thyroid Associationvol. By supplementing just two capsules of DIM, the average person would need to eat as much as two pounds of cruciferous vegetables per day, to get the same benefits. A., and Kim, Y. S. Estrogen receptor alpha as a target for indole-3-carbinol. J.Nutr. Indole-3-carbinol. Case Rep Med. 1978;38(5):1410-1413. J Allergy Clin Immunol Pract. About one-fourth of the women experienced an increase in bowel frequency, while 18 percent had headaches or gas. Cancer Epidemiol.Biomarkers Prev. l-Methionine is an essential amino acid that supports glutathione production and encourages healthy liver function, including phase II detoxification pathways, healthy hepatic fat metabolism, and bile flow. When you eliminate these addictive, toxic foods and drinks, you may initially have uncomfortable reactions like feeling achy, flu-like feelings, irritability, nausea, headaches, brain fog, constipation, hunger, itchy skin, fatigue and sleep difficulties. Depending on the nature of your detox, you may not eliminate these headaches but there are ways to make them bearable. View abstract. Amazon.com: Dim Detox 2006;17(10):659-664. View abstract. Biochem.Pharmacol. View abstract. Diindolylmethane (DIM) is a metabolite of Indole-3-carbinol (I3C), a compound found in cruciferous vegetables including broccoli, cabbage, and cauliflower.It is the most studied of all I3C metabolites and is thought to be superior to IC3 as a chemoprotective compound for breast cancer and prostate cancer .. Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Always consult your physician or qualified health professional on any matters regarding your health. Support and guidance are often needed if someone wants the best possible chance at achieving long-term recovery. Prostate 4-1-2006;66(5):453-462. View abstract. Pre-menopausal and post-menopausal symptoms are caused by fluctuations and the eventual decrease of estrogens in a womans aging body. Vomiting and Stomach Cramps Diarrhea Increased Irritability Tachycardia (increased heart rate) Hypertension (elevated blood pressure) Myoclonus (muscle spasms) With the physical symptoms reducing during the second week and stomach issues resolving, being able to eat and sleep more may help improve the subjective experience of other symptoms. 1993;46(6):791-798. Are you ready to take control of your vein problems and finally look AND feel your best this year? If this becomes a problem, talk to your doctor. I've heard that the first few days on DIM can feel like a detox. What Dextromethorphan Withdrawal Timeline, Symptoms, Effects - Detox Local Many detox diets allow natural drinks as long as they dont contain added sugars, preservatives, or pasteurization. The most common of these symptoms are. . We believe thateveryone can optimize not only their athletic, but their human potential. In fact, many of the people that have the most significant gains from DIM will experience headaches or fatigue in the first few days. But using DIM may help reduce polycystic ovary syndrome symptoms. Zhao, Y. Y., Zhou, L., Pan, Y. However, DIM doesnt burn fat. Estrogen Dominance: When an Unhealthy Gut Estrobolome is to Blame View abstract. Toxicol.Sci. If you have liver or kidney disease, or are at a higher risk for estrogen-sensitive cancers or hormone-related conditions, consult your physician before taking DIM. See additional information. Research indicates that dietary intake of lignans such as 7-hydroxymatairesinol (HMR), and healthy serum enterolactone levels provide support for cellular, heart, breast, bone and cognitive health. The good news is that following an estrogen detox diet can help balance out your hormone levels and reverse estrogen dominance naturally and safely. Zhonghua Yi.Xue.Za Zhi. 21,3 (2011): 299-304. Made for the elite athlete and the strong-willed our products were designed to fuel your athletic performance. DIM Supplements: Benefits, Side Effects, and Dosage - Healthline The British Journal of Cancer conducted a random control trial looking at woman at risk for developing cervical cancer. The third week is often much improved from a physical standpoint, with almost all physical symptoms as well as insomnia frequently being resolved or very close to it. Vermillion Maier ML, Siddens LK, Uesugi SL, et al. Detox headaches are often caused by your bodys reaction to missing an item, such as sugar or caffeine, that was habitually present. McDougal A, Gupta MS, Ramamoorthy K, et al. Silymarin, alpha lipoic acid and n-acetyl-l-cysteine act to support phase II detoxification enzyme activity in the liver and offer antioxidant support for cellular protection. Cancer Epidemiol.Biomarkers Prev. While these events may have some benefits, they wildly oversimplify the concept of detoxification. Detoxification, by Jonah Udall Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Ann N Y Acad Sci 1999;889:204-13. Hsu, J. C., Zhang, J., Dev, A., Wing, A., Bjeldanes, L. F., and Firestone, G. L. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. McGuire, K. P., Ngoubilly, N., Neavyn, M., and Lanza-Jacoby, S. 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. The study in "BMC Cancer" reported that different concentrations of DIM may lead to different biological outcomes. Information from this source is evidence-based and objective, and without commercial influence. Consult with your doctor before beginning a detox program to make sure that its a safe undertaking for you based on your current health. Glutamate is a major excitatory neurotransmitter in the brain that has a multitude of roles, and the fact that dextromethorphan acts as an antagonist at NMDA glutamate receptors means that it can reduce the excitatory impact produced by glutamate. Instead, it boosts your bodys capacity to metabolize estrogen, so your lifestyle choices (diet, exercise, etc.) ~HB Support. View abstract. But something that helps take away the side effects of DIM is Calcium-D-Glucarate. View abstract. Contact Evexias Denver Medical Centers and make an appointment today! The contents of thisblogshould not be taken as medical advice. View abstract. DIM is a phytoestrogen and not an anti-estrogen DIM blocks mTOR and subsequently inhibits growth Very low doses of DIM as found as a component of foods with the necessary cofactors works in the gut and liver to manipulate estrogen detox and support healthy estrogen metabolite ratios to prevent estrogen dominance Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes. The way we believe we can optimize performance is through. Smith, T. K., Lund, E. K., Clarke, R. G., Bennett, R. N., and Johnson, I. T. Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro. The results showed that after supplementing with 150mg of DIM for 6 months, 70 percent experienced at least one non-serious side effects. Wang, T. T., Milner, M. J., Milner, J. Kale. 6-1-2009;107(3):516-527. Ahmad, A., Kong, D., Sarkar, S. H., Wang, Z., Banerjee, S., and Sarkar, F. H. Inactivation of uPA and its receptor uPAR by 3,3'-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration. Alcohol withdrawal delirium (AWD) is the most serious form of alcohol withdrawal. DIM & Detox offers support for antioxidant defence and function of the liver, an organ essential to the bodys detoxification. These enzymes are involved in the elimination and metabolism of toxins, carcinogens, and steroid hormones like estrogen. Techniques and remedies to try include: Breathing can expel toxins and long, slow breathing may relax you and ease your headache. Sometimes it may block the effect of estrogen, while it may enhance estrogen activity in other circumstances. J.Biol.Chem. While the most physically uncomfortable time may be passed by this point, there is still work to be done. Glucosinolates in broccoli, including indole-3-carbinol and sulforaphane, help support healthy detoxification. Dehydration can cause headaches. Mol.Carcinog. Estrogen Dominance Detox Diet: The 21 Foods To Reverse It Naturally Riby, J. E., Xue, L., Chatterji, U., Bjeldanes, E. L., Firestone, G. L., and Bjeldanes, L. F. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. 2008;25(9):2117-2124. Inflamm.Bowel.Dis. Detox symptoms should only last three to seven days. These include: Weight gain Bloating Acne Headaches Worsened PMS symptoms Emotional disturbances ( depression, anxiety, mood swings) Cancer Detect.Prev. italica) Sprout Std. When these levels are higher than average in a woman, a hormone imbalance occurs causing insulin resistance, irregular menstrual periods, and an increase in testosterone and other male hormones. View abstract. View abstract. View abstract. Rahman, K. W., Li, Y., Wang, Z., Sarkar, S. H., and Sarkar, F. H. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Not only can it result in estrogen dominance symptoms; if not properly detoxified, it increases the risk of several cancers. We will inform you when the product arrives in stock. View abstract. DIINDOLYLMETHANE: Overview, Uses, Side Effects, Precautions - WebMD Yasuda, Michiko T et al. The statements made regarding some or all products have not been evaluated by the Food and Drug Administration. Stroke. Increasing consumption of cruciferous vegetables and DIM can help. Dextromethorphan, also known as DXM, is a common ingredient in cough medications such as Robitussin, and until recently, there were no regulations regarding the sale of dextromethorphan in America. Anticancer Drugs 1998;9(2):141-148. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. WebMD does not provide medical advice, diagnosis or treatment. Firestone, G. L. and Bjeldanes, L. F. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. Suite 110 Hi, some find that when they start DIM, certain symptoms get worse. It may also have an anti-testosterone impact. View abstract. Detox headaches are often caused by your body's reaction to missing an item, such as sugar or caffeine, that was habitually present. Most people use DIM for about 6-12 months, but you can take DIM for as long as needed. When youre participating in a detox, its common to experience headaches. Turnips. Fatty liver disease. Female sex hormones including estrogen and progesterone help conduct our sleep cycle and overall mood. If the lowest dose isnt effective after a month or so, your doctor will increase the dose over time until your symptoms are significantly relieved. The symptoms of dextromethorphan withdrawal can also vary in both intensity and duration, sometimes substantially, between different people. The bottom line is that DIM may cause hormonal disturbances, reports NYU Langone Medical Center. Not Taking DIM is not an option. Sometimes the diet includes herbs and other natural supplements. Through long-term and heavy use of dextromethorphan, the systems that were affected will undergo changes. View abstract. View abstract. Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. But sometimes dietary intake is not enough, and thats when DIM in supplemental form can prove extremely beneficial and crucial for efficient detoxification. It's not for me. As a result, the ratio of progesterone increases. 2006;69(2):430-439. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. If you choose to stop taking DIM supplements, you do not need to wean yourself off of it. Then they progress to a strict diet of water, fresh fruit and vegetable juices, and raw fruits and vegetables. PLoS One 2013;8(9):e74916. DIM is considered nontoxic, but more research is needed to fully determine its safety. Withdrawal is a tough obstacle in overcoming opiate addiction, but you can get through it. Biochem Biophys Res Commun 1996;228:153-8. There are several other stimulant drugs that can produce uncomfortable or even dangerous withdrawal symptoms. Cell Cycle 2005;4(9):1201-1215. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. While they are less intense than the acute symptoms, they often fade gradually over time. 2007 Oct;6(10):2757-65. Once these upregulation and downregulation processes have begun to occur, someone will begin to feel unwell when they go too long without dextromethorphan. Bad estrogen associated with obesity has been implicated as one of the primary risk factors in the development of cancer-causing tumors in breast tissue[R], In addition to keeping good estrogen in the body, DIM also works to inhibit aromatase, the enzyme that converts testosterone into estrogen. Clin.Cancer Res. Li, Y., Li, X., and Guo, B. Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Mustard Greens. Carcinogenesis 2006;27(4):717-728. View abstract. For example, DIM has an anti-estrogenic effect, which may reduce the risk of developing thyroid cancer, according to a study in "Thyroid" in March 2011. View abstract. DIM may interact with medications, so avoid supplements if you take prescription medications. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. "Detox Symptoms" There is no research supporting the existence of "detox symptoms" with calcium-D-glucarate. 2007;137(1):31-36. Sepkovic, D. W., Bradlow, H. L., and Bell, M. Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol. J.Nutr. How To Break Your Sugar Addiction - Cleveland Clinic We believe thateveryone can optimize not only their athleticperformancebut their human potential. Extract (20:1, 1000 mg dried equivalent), HMRlignan 7-hydroxymatairesinol potassium acetate, Milk thistle (Silybum marianum) Seed Std. While it might not feel like it at the time, these symptoms are short-lived and will pass. McDougal, A., Gupta, M. S., Morrow, D., Ramamoorthy, K., Lee, J. E., and Safe, S. H. Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Varicose Veins Risks: How to Avoid Blood Clots, Exclusive promos and specials on our services, Important announcements and treatment offerings. Learn tips to help relief pain like drinking more water and using relaxation techniques. View abstract. Fullscript | DIM & Detox View abstract. The Truth About DIM Supplements (Diindolylmethane) Last medically reviewed on July 17, 2018. Thats because women with PCOS have high levels of androgens. 00 ($0.68/Count) Save more with Subscribe & Save. 2010;49(7):672-683. Overweight or obesity. Ge X, Yanni S, Rennert G, et al. DIM Detox includes ingredients to support healthy detoxification, estrogen metabolism, and cell cycle activity: *These statements have not been evaluated by the FDA and are not intended to treat or cure any disease. Diindolylmethane might have effects similar to estrogen. You can learn more about how we ensure our content is accurate and current by reading our. This Nrf2/ARE process serves a protective role in the body. Degner, S. C., Papoutsis, A. J., Selmin, O., and Romagnolo, D. F. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. DIM - Side effects? Detoxing symptoms? : r/Supplements - Reddit These are strictly psychological in nature, but they can still be present significant challenges to someones continued sobriety and health. These are the symptoms of dextromethorphan withdrawal, and depending on someones use habits, they may range from a little uncomfortable, to potentially life-threatening. Altern Med Alert 2000; 3:105-7. Suite 110 Denver, CO 80222, Many of the people who come to our clinic for vein removal also use the services at our sister clinic, Evexias Medical Denver. file size: 10 MB. Yet, DIM has so many other notable benefits beyond hormonal health that can improve overall health and wellness. nccih.nih.gov/health/pain/headachefacts.htm, mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/expert-answers/detox-diets/faq-20058040, Alcohol Withdrawal Syndrome: Symptoms, Causes, Treatment, and More, Opiate Withdrawal: What It Is and How to Cope with It, Home Remedies to Ease Opiate Withdrawal Symptoms. View abstract. Should I take DIM if I have low estrogen? View abstract. View abstract. View abstract. View abstract. All Products, DIM Detox. Here, were just talking about the length of time it takes for DIM to work. Some people may even stop the use of these helpful natural substances before their body has a chance to fully rid itself of the toxins due to these detox symptoms. DIM Supplement: How Long Does it Take to Work? In other words, DIM helps our bodies get rid of what it doesn't need and create what it does. For some women, it may take six months to see optimal results. There really is no such thing as a detox, in general. Biochem Pharmacol 2000;60:167-77. Regulating estrogens is the key to supporting menopausal symptom relief. We have more in-depth withdrawal guides for drugs such as: Disclaimer: The information provided on DetoxLocal.com is intended for educational purposes and is not a substitute for professional medical treatment. View abstract. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Hong, C., Firestone, G. L., and Bjeldanes, L. F. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. View abstract. View abstract. Available at: https://ntp-server.niehs.nih.gov. Cancer Res. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Being overweight experience increase in estrogen dominance especially those who carry weight around their midline. 39 10. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer.