Ashwaganda and Xanax Interactions Checker - Drugs.com We comply with the HONcode standard for trustworthy health information. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. View abstract. Dasgupta A, Tso G, Wells A. Indian J Med Res 2015 Jan;141(1):100-6. Mandlik Ingawale DS, Namdeo AG. Upadhaya L and et al. Additionally, ashwagandha may increase testosterone levels in the body. View abstract. Some don't work well with prescription medicines. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. Kulkarni RR, Patki PS, Jog VP, et al. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Ashwagandha Side Effects + Drug Interactions - Vida Optima . Begum, V. H. and Sadique, J. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. J Atten Disord 2010;14:281-91. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Take extra care if you are taking drugs to help with your thyroid. In rare cases, the use of ashwagandha may lead to liver damage. Am J Drug Alcohol Abuse 2009;35(1):1-11. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. As with many other herbal supplements, little research is available on possible interactions. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Thyroid Suppression Test. View abstract. View abstract. You will need to talk about the benefits and risks of using this natural product. Ashwagandha may be toxic to the liver (hepatotoxic). This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. J Clin Psychiatry. Anbalagan, K. and Sadique, J. Taking high doses of ashwagandha may increase your risk of side effects. Doctors prescribe immunosuppressants for people with conditions such as rheumatoid arthritis, psoriasis and ulcerative colitis, and to prevent rejection of organ transplants. Herb-drug interactions. Take extra care if you are at a high risk for infection. Use birth control you can trust while taking this product. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. Evid Based Complement Alternat Med. View abstract. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. For more information, read the "What else do I need to know?" section below. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Antidepressants come in various forms. Jahanbakhsh SP, Manteghi AA, Emami SA, Mahyari S, et al. Some barbiturates include phenobarbital, pentobarbital and secobarbital. Nonetheless, additional large-scale, long-term studies would strengthen these findings. View abstract. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Medically reviewed by Drugs.com. doi:10.7759/cureus.5797, Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of ashwagandha (Withania somnifera) extract on sleep: a systematic review and meta-analysis. Herbal supplements and heart medicines may not mix - Mayo Clinic doi:10.1371/journal.pone.0257843, Verma N, Gupta SK, Tiwari S, Mishra AK. This holds true for ashwagandha. View abstract. Be sure to tell your doctor if you are breastfeeding. What Vitamins Can You Not Take With Anti-Depressants? It may also interact with other herbs, supplements, and even foods. 2012;10(1):48-9. View abstract. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. Ashwagandha supplements are meant to be taken every day. Role of an indigenous drug Geriforte on blood levels of biogenic amines and its significance in the treatment of anxiety neurosis. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. With such a long list of claims, it's important to look closely at the research. Ashwagandha (Withania somnifera) is a natural herb used for centuries in Ayurveda. Other essential vitamins and minerals may also be helpful in treating depression. This dosing has also been associated with improvements in memory. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Effect of a medicinal plant (Passiflora incarnataL) on sleep. Does ashwagandha help with erectile dysfunction? - Medical News Today Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. 2021 Nov 25;13(2):100510. J Funct Morphol Kinesiol. Cureus. J Ethnopharmacol. Can Ashwagandha and SSRI be taken together? - iCliniq View abstract. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions However, the review noted various limitations of the studies, including study design and potential bias. Taking ashwagandha along with diabetes medications might cause blood sugar to drop too low. View abstract. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. Nat.Prod.Res 2005;19(6):567-571. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Ashwagandha side effects. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Kuppurajan K, Rajagopalan SS, Sitoraman R, and et al. Myxedema Coma. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. Select a condition to view a list of vitamins. There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. I was told that I had an allergic reaction to penicillin when I was a child. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Does Ashwagandha Interact With Any Medications? Can I Take Lexapro & Vitamin Supplements? View abstract. Adaptogenic Herbs And Their Interaction With Medications - Thyroid Nation Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Cancer Lett. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Take extra care and check with your doctor if you have: Signs of a very bad reaction. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. The roots can be used topically as a poult. Ashwagandha and other dietary supplements should never replace standard medicine or care. Some of the more compelling potential uses of ashwagandha are outlined below. Although ashwagandha is mainly considered safe, side effects may be possible. J Clin Med 2021;10(16):3644. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Ashwagandha may be used for anxiety due to its perceived anti-inflammatory and antioxidant properties. View abstract. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. 2019;11(12):e6466. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. TSH Suppression. Cureus. Curr Res Toxicol. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). PLoS.One. Mikolai, J., Erlandsen, A., Murison, A., Brown, K. A., Gregory, W. L., Raman-Caplan, P., and Zwickey, H. L. In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Phytother Res. Several supplements and herbs may act similarly to ashwagandha. J Neurol Sci 2000;176:124-7. J Ethnopharmacol 1991;33:91-5. They should also be kept from direct sunlight and stored in their original bottle or container. If you are experiencing serious medical symptoms, please see the According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Brain Behav. 2021;2021:8254344. doi:10.1155/2021/8254344, Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) root extract in improving memory and cognitive functions. Some products may not mix well with other drugs or natural products. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. This is according to a recent review of case studies of liver damage caused by ashwagandha. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. . Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network. Chitre D, Nadkarni S, Jagtap N, et al. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Ashwagandha - Benefits | Side-Effects | Safety Concerns | Interactions Xanax. and treatment options, including any risks or benefits regarding use of medications. Ashwagandha appears to stimulate your endocrine system . J Med Food 2022. Phytotherapy Research 1991;5:111-114. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. WebMD does not provide medical advice, diagnosis or treatment. J R Coll Physicians Edinb. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Herbs like Ashwagandha are known to interact with SSRI and other medicines. This information does not contain all possible interactions or adverse effects. Ashwagandha has mild interactions with at least 29 different drugs. The combination could decrease the effectiveness of these medications. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Ashwagandha Blood Pressure Medication Interaction What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. J Funct Morphol Kinesiol. If you're taking antidepressants and vitamins at the same time, be aware of the ingredients in your vitamin supplements. Biochem.Biophys.Res Commun. For insomnia, a dose of 600 milligrams per day has been found to be safe and effective. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Underactive Thyroid. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. View abstract. By Brittany Lubeck, RD View abstract. Its effects on arterial blood pressure in anaesthetized dogs. Skinmed. View abstract. It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. 2012;10(1):48-49. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Taking ashwagandha along with these medications might decrease the effects of these medications. Skinmed. Ashwagandha can interact with diabetes, blood pressure, and immunosuppressant medications. Cancer Lett 2000;148:9-17. Durg S, Bavage S, Shivaram SB. These include drugs like thyroid desiccated, levothyroxine, or liotrix. Do not use this product if you have stomach problems or ulcers. Insomnia is a common sleep disorder that is defined as an inability to get adequate sleep. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. ashwagandha - medtigo Ashwagandha | Memorial Sloan Kettering Cancer Center Hence, be cautious if taking these medications and want to take Ashwagandha also. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. Holistic Medicine 42 years experience. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Mental health statistics show between 3 and 5 percent of adults live with a depressive disorder globally, according to a January 2014 study in Depression and Anxiety. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). View abstract. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Chauhan S, Srivastava MK, Pathak AK. Of the 58 participants in the study, those who took ashwagandha had reduced levels of cortisol (a stress hormone) as well as lower perceived stress scores by the end of the eight-week study. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. Am J Ther 2023;30(1):e80-e83. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Ashwagandha Dosage: How Much Ashwagandha Per Day? - Healthgrades Fortunately, no cases resulted in liver failure, and all recovered. View abstract. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Be aware that antidepressants and vitamins typically work with each other the vitamins won't replace your medication. All rights reserved. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Varying levels of research have looked at the potential benefits of ashwagandha. View abstract. Hi, I was recommended to take ashwagandha. Cureus 2022;14(10):e30433. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. The length of use of ashwagandha ranged from 14 to 110 days, and doses ranged from 450 milligrams to 1,350 milligrams per day. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Biogerontology. Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. Hypothyroidism, After Thyroid Removal. Some medications, called sedatives, can also cause sleepiness and slowed breathing. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Cureus. Int.J.Crude Drug Res. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. It is also important to note that ashwagandha may interact with certain medications, such as immunosuppressants and sedatives. Food Chem.Toxicol. Ashwagandha's cortisol-lowering effects may be responsible. 1985;23(4):177-183. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. 2020;40(4):825-829. . Prog.Neuropsychopharmacol.Biol.Psychiatry 7-1-2008;32(5):1093-1105. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. The liver damage never progressed to liver failure, and most cases were resolved within five months. PLoS One. Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). 2017 Jan;22(1):96-106 View abstract. Ghosal S, Lal J, Srivastava R, and et al. There are a variety of vitamins and minerals that are essential for good health. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. Indian J Exp Biol 1997;35:236-9. In this investigation, participants took either a placebo or 240 milligrams per day of ashwagandha extract. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. View abstract. Available for Android and iOS devices. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Is it safe to take ashwagandha every day? Vaishnavi, K., Saxena, N., Shah, N., Singh, R., Manjunath, K., Uthayakumar, M., Kanaujia, S. P., Kaul, S. C., Sekar, K., and Wadhwa, R. Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences. Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study.

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